Neuroimmunology —
Research Group Prof. Dr. Natalia Pikor
Prof. Dr. Natalia Pikor's research group is investigating how immune responses are regulated in the central nervous system. In this sensitive organ, it is particularly important to limit excessive immune responses and still provide protection against pathogens. It is known that this regulation originates from fibroblasts, among others, but the exact mechanisms are not yet fully understood. A deeper understanding of immune regulation may pave the way for new therapeutic approaches.
Current research activities
In the research database of HOCH Health Ostschweiz you will find an insight into the research activities of Prof Dr Pikor. Below you will find a selection of current projects:
Immune responses against viruses in the brain
Viruses can remain in the brain after an acute infection. Although the immune system can contain the virus, it cannot completely eliminate it, which can lead to a resurgence of the viral infection.
Virus-specific antibodies play a crucial role in the elimination and containment of viruses. This project is investigating how fibroblasts and immune cells interact and what factors are needed to prevent the resurgence of viral infections.
Funding: Swiss National Science Foundation
Immune response against coronaviruses in the digestive tract
While most human coronaviruses primarily cause respiratory diseases, certain variants can also infect other organs such as the gastrointestinal tract or liver. However, the underlying mechanisms and consequences of such infections are still poorly understood. In this project, the infection processes in these organs and the reactions of the body's immune defence are being investigated. The aim is to identify risk factors, understand the effects of such infections and develop new approaches for therapies.
Funding: Peter Hans Hofschneider Endowed Professorship
Brain tumours: Control of T cells by fibroblasts
Brain metastases are among the most common tumours of the central nervous system and are one of the main causes of death in cancer patients. Despite modern immunotherapies, their treatment is difficult, partly because only a few immune cells, such as T cells, are present in the tumour tissue. Cancer-associated fibroblasts are considered important regulators of the immune response, as they can both activate and inhibit immune cells. However, their role in brain metastases is poorly understood. This project will investigate whether and how fibroblasts help to form a specialised environment within the tumour to control immune responses in tumour tissue. A deeper understanding of these processes may help to identify new, more effective immunotherapies.
Funding: Helmut Horten Foundation
Contact
